Advances in Pharmacology and Clinical Trials

The current study is a companion piece of an earlier study by Colburn published in August 1983 Issue of the Journal of Pharmacokinetics and Biopharmaceutics; therefore the data published in the study cited here were used. For modeling purposes, an advanced mathematical modeling method based on the theory of dynamic systems was employed. The modeling method employed, has been introduced to pharmacokinetics in the study by Dedík et al. entitled: “Estimation of influence of gastric emptying on shape of glucose concentration-time profile measured in oral glucose tolerance test”, published in September 2007 Issue of the journal Diabetes Research and Clinical Practice. The goal of the current study was to continue presenting some interesting views on a successful use of an advanced mathematical modeling method based on the theory of dynamic systems in a pharmacokinetic study. The mathematical model of the pharmacokinetic behavior of warfarin was developed using the data from the study cited above. The mathematical model developed successfully described the pharmacokinetic behavior warfarin in the subject described in the study by Colburn.